刊物

論文 —— 臨床試驗成果

結腸直腸癌

Van Hazel G, Blackwell A, Anderson J, et al. Randomised phase 2 trial of SIR-Spheres plus Fluorouracil/Leucovorin chemotherapy versus Fluorouracil/Leucovorin chemotherapy alone in advanced colorectal cancer. Journal of Surgical Oncology 2004;88:78 - 85.

Gray B, Van Hazel G, Hope M, et al. Randomised trial of SIR-Spheres plus chemotherapy vs chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Annals of Oncology 2001;12:1711 - 1720.

肝細胞癌

Lau W, Leung W, Ho S, et al. Treatment of inoperable hepatocellular carcinoma with intra-hepatic arterial yttrium-90 microspheres: a phase I and II study. British journal of Cancer 1994;70:994 - 999.

論文 —— 臨床經驗成果

結腸直腸癌

Kennedy A, Coldwell D, Nutting C, et al: Resin 90Y-microsphere brachytherapy for unresectable colorectal liver metastases: Modern USA experience. International Journal of Radiation Oncology, Biology and Physics 2006;65:412  425.

Lim L, Gibbs P, Yip D, et al. A prospective evaluation of treatment with Selective Internal Radiation Therapy (SIR-Spheres) in patients with unresectable liver metastases from colorectal cancer previously treated with 5-FU based chemotherapy. BMC Cancer 2005;5:132.

Wong C, Qing F, Savin M, et al. Reduction of metastatic load to liver after intraarterial hepatic yttrium-90 radioembolization as evaluated by [18F]Fluorodeoxyglucose positron emission tomographic imaging. Journal of Vascular and Interventional Radiology 2005;16:1101 - 1106.

Murthy R, Xiong H, Nunez R, et al. Yttrium 90 Resin microspheres for the treatment of unresectable colorectal hepatic metastases after failure of multiple chemotherapy regimens: Preliminary results. Journal of Vascular and Interventional Radiology 2005;16:937 - 945.

Stubbs R, Wickremesekera S. Selective internal radiation therapy (SIRT): a new modality for treating patients with colorectal liver metastases. HPB 2004;6:133 - 139.

Stubbs R, Cannan R, Mitchell A. Selective Internal Radiation Therapy (SIRT) with 90Yttrium Microspheres for Extensive Colorectal Liver Metastases. Hepato-Gastroenterology 2001;48:333 - 337.

Gray B, Van Hazel G, Buck M, et al. Treatment of colorectal liver metastases with SIR-Spheres plus chemotherapy. GI Cancer 2000;3:249 - 257.

Stubbs R, Cannan R, Mitchell A, et al. An initial experience with selective internal radiation therapy (SIRT) for non-resectable colorectal liver metastases. Gastrointestinal Cancer 1999;3:135 - 143.

Stubbs R, Cannan R. Active treatment of colorectal hepatic metastases. New Zealand Family Physician 1999;26.

Gray B, Anderson J, Burton M, et al. Regression of liver metastases following treatment with yttrium-90 microspheres. Australian and New Zealand journal of Surgery 1992;62:105 - 110.

Gray B, Burton M, Kelleher D, et al. Selective internal radiation (SIR) therapy for treatment of liver metastases: measurement of response rate. Journal of Surgical Oncology 1989;42:192 - 196.

肝細胞癌

Chui A, Rao A, Island E, et al: Multimodality tumor control and living donor transplantation for unresectable hepatocellular carcinoma. Transplantation Proceedings 2004;36:2287  2288.

Lau W, Ho S, Yu S, et al. Salvage surgery following downstaging of unresectable hepatocellular carcinoma. Annals of Surgery 2004;240:299 - 305.

Szeto C, Wong T, Leung C, et al. Selective internal radiation therapy by yttrium-90 microspheres for hepatocellular carcinoma after renal transplantation. Clinical Transplantation 2001;15:284 - 288.

Lau W, Ho S, Leung T, et al. What determines survival duration in hepatocellular carcinoma treated with intraarterial yttrium-90 microspheres? Hepato-Gastroenterology 2001;48:338 - 340.

Lau W, Ho S, Leung T, et al. Selective Internal Radiation Therapy for non-resectable hepatocellular carcinoma with intraarterial infusion of 90-yttrium microspheres. International Journal of Radiation Oncology, Biology and Physics 1998;40:583 - 592.

乳腺癌

Rubin D, Nutting C, Jones B. Metastatic breast cancer in a 54-year-old woman: Integrative treatment with yttrium-90 radioembolization. Integrative Cancer Therapies 2004;3:262 - 267.

各種致癌源

Poepperl G, Helmberger T, Munzing W, et al. Selective Internal Radiation Therapy with SIR-Spheres in Patients with Nonresectable Liver Tumors. Cancer Biotherapy & Radiopharmaceuticals 2005;20:200 - 208.

Lim L, Gibbs P, Yip D, et al. Prospective study of treatment with selective internal radiation therapy spheres in patients with unresectable primary or secondary hepatic malignancies. Internal Medicine Journal 2005;35:222 - 227.

論文 —— 評論文章

Garrean S, Espat N. Yttrium-90 internal radiation therapy for hepatic malignancy. Surgical Oncology 2005;14:179  193.

Thomadsen B, Welsh J, Hammes R. Microspheres as Microbrachytherapy, in Thomadsen B, Rivard M, Butler W (eds): Brachytherapy Physics (2nd Edition). Madison, Wisconsin, Medical Physics Publishing, 2005, pp 955  965.

Clark H, Carson W, Kavanagh P, et al. Staging and Current Treatment of Hepatocellular Carcinoma. Radiographics 2005;25:S3 - S23.

Coldwell D, Sewell P. The Expanding Role of Interventional Radiology in the Supportive Care of the Oncology Patient: From diagnosis to Therapy. Seminars in Oncology 2005;32:169  173.

Stubbs R. Local Radio Ablative Techniques for Liver Tumors. 2nd ed. Sudbury, Massachusetts: Jones and Bartlett; 2003.

Liu L, Zhang W, Jiang H. Current treatment for liver metastases from colorectal cancer. World Journal of Gastroenterology 2003;9:193 - 200.

Stubbs R, Cannan R. Selective Internal Radiation Therapy with 90-Yttrium Microspheres for Primary or Metastatic Cancer Confined to the Liver. In: Habib N, editor. Multi-Treatment Modalities of Liver Tumours. New York: Kluwer Academic/Plenum Publishers; 2002. pp. 305 - 321.

Lau W, Ho S, Leung T. Internal Radiation Therapy Through the Hepatic Artery. In: Habib N, editor. Multi-treatment Modalities of Liver Tumours. New York: Kluwer Academic/Plenum; 2002.

Buscombe J. Interventional Nuclear Medicine in Hepatocellular Carcinoma and other tumours. Nuclear Medicine Communications 23:837 - 841, 2002.

Stubbs R, Cannan R, Mitchell A. Selective Internal Radiation Therapy with yttrium-90 microspheres for extensive liver metastases. Journal of Gastrointestinal Surgery 2001;5:294 - 302.

Moroz P, Gray B. Radiotherapy in the Treatment of Advanced Liver Cancer: Current Status and Future Directions. Asian Journal of Surgery 2000;23:32 - 41.

Ho S, Lau W, Leung T, et al. Internal radiation therapy for patients with primary or metastatic hepatic cancer. Cancer 1998;83:1894 - 1907.

Ho S, Johnson P, Leung W, et al. Combating hepatocellular carcinoma with an integrated approach. Chinese Medical Journal 1998;112:80 - 83.

Ngan H. Imaging and radiological intervention in hepatocellular carcinoma. Hong Kong Medical Journal 3:57 - 68, 1997.

Willmott N, Daly J, Gray B. Perspectives in the management of liver metastases. In: Willmott N, Daly J, editors. Microspheres and regional cancer therapy: CRC Press Inc; 1994. pp. 229 - 235.

論文 —— 機理文章

Gulec S, Mesoloras G, Stabin M. Dosimetric techniques in 90Y-microsphere therapy of liver cancer: The MIRD equations for dose calculations. J Nucl Med 2006; 47:1209 - 1211.

Bienert M, McCook B, Carr B, et al: 90Y microsphere treatment of unresectable liver metastases: changes in 18F-FDG uptake and tumour size on PET/CT. European Journal of Nuclear Medicine and Molecular Imaging 2005; 32:778 - 787.

Dhabuwala A, Lamerton P, Stubbs R. Relationship of 99mtechnetium labelled macroaggregated albumin (99mTC-MAA) uptake by colorectal liver metastases to response following Selective Internal Radiation Therapy (SIRT). BMC Nuclear Medicine 2005;5.

Murthy R, Nunez R, Szklaruk J, et al. Yttrium-90 Microsphere Therapy for Hepatic Malignancy: Devices, Indications, Technical Considerations, and Potential Complications. Radiographics 2005;25:S41 - S55.

Kennedy A, Nutting C, Coldwell D, et al. Pathologic response and microdosimetry of 90Y microspheres in man: review of four explanted whole livers. International Journal of Radiation Oncology, Biology and Physics 2004;60:1552-1563.

Moroz P, Anderson J, Van Hazel G, et al. Effect of Selective Internal Radiation Therapy and Hepatic Arterial Chemotherapy on Normal Liver Volume and Spleen Volume. Journal of Surgical Oncology 2001;78:248 - 252.

Campbell A, Bailey I, Burton M. Tumour dosimetry in human liver following hepatic yttrium-90 microsphere therapy. Physics in Medicine and Biology 2001;46:487 - 498.

Campbell A, Bailey I, Burton M. Analysis of the distribution of intra-arterial microspheres in human liver following hepatic yttrium-90 microsphere therapy. Physics in Medicine and Biology 2000;45:1023 - 1033.

Halley S, Walker T, Gray B, et al. Microsphere Distribution within a Metastatic Liver Tumour Following Selective Internal Radiation Therapy. GI Cancer 2000;3:193 - 197.

Ho S, Lau W, Leung T, et al. Clinical evaluation of the partition model for estimating radiation doses from yttrium-90 microspheres in the treatment of hepatic cancer. European Journal of Nuclear Medicine 1997;24:293 - 298.

Ho S, Lau W, Leung T, et al. Tumor-to-normal uptake ratio of Y-90 microspheres in hepatic cancer assessed with Tc-99-m macroaggregated albumin. British journal of Radiology 1997;70:823 - 828.

Ho S, Lau W, Leung T, et al. Partition model for estimating radiation doses from yttrium-90 microspheres in treating hepatic tumors. European Journal of Nuclear Medicine 1996;23:947  952.

Fox R, Klemp P, Egan G, et al. Dose distribution following selective internal radiation therapy. International journal of Radiation Oncology, Biology and Physics 1991;21:463 - 467.

Gray B, Matz L, Burton M, et al. Tolerance of the liver to yttrium-90 irradiation. International journal of Radiation Oncology, Biology and Physics 1990;18:619 - 623.

Burton M, Gray B, Kelleher D, et al. Selective internal radiation therapy: validation of intraoperative dosimetry. Radiology 1990;175:253 - 255.

Archer S, Gray B. The vascularisation of small liver metastases. British Journal of Surgery 1989;76:545-548.

Burton M, Gray B, Klemp P, et al. Selective internal radiation therapy: Distribution of radiation in the liver. European Journal of Cancer and Clinical Oncology 1989;25:1487 - 1491.

Klemp P, Perry A, Fox R, et al. Aspects of radiation protection during the treatment of liver cancer using yttrium-90 labeled microspheres. Radiation Protection in Australia 1989;7:70 - 73.

Chamberlain M, Gray B, Heggie J, et al. Hepatic metastases: a physiological approach to treatment. British Journal of Surgery 1983;70:596 - 598.

Stribley K, Gray B, Chmiel R, et al. Internal radiotherapy for hepatic metastases: The homogenicity of hepatic arterial blood flow. Journal of Surgical Research 1983;33:17 - 24.

Stribley K, Gray B, Chmiel R, et al. Internal radiotherapy for hepatic metastases: The blood supply of hepatic metastases. Journal of Surgical Research 1983;33:25 - 32.

論文 —— 治療事宜

Ayav A, Habib N, Jiao L. Portal Hypertension Secondary to 90Yttrium Microspheres: An Unknown Complication. Journal of Clinical Oncology 23:8275 - 8276, 2005.

Response to Ayav et al: Stubbs R. Portal Hypertension and Liver Surgery Following Selective Internal Radiation Therapy With 90Yttrium Microspheres. Journal of Clinical Oncology 24:15e, 2006.

Yip D, Allen R, Ashton C, et al. Letter: Radiation-induced ulceration of the stomach secondary to hepatic embolization with radioactive yttrium microspheres in the treatment of metastatic colon cancer. Journal of Gastroenterology and Hepatology 2004;19:347 - 349.

Thamboo T, Tan K, Wang S, et al. Extra-hepatic embolisation of Y-90 microspheres from selective internal radiation therapy (SIRT of the liver. Pathology 2003;35:351 - 353.

Wickremesekera J, Chen W, Cannan R, et al. Serum proinflammatory cytokine response in patients with advanced liver tumors following selective internal radiation therapy (SIRT) with yttrium-90 microspheres. International journal of Radiation Oncology, Biology and Physics 2001;49:1015 - 1021.

Ho S, Lau J, Leung T. Intrahepatic Y-90 microspheres for hepatocellular carcinoma. Journal of Nuclear Medicine 2001;42:1587 - 1588.

Leung T, Lau W, Ho S, et al. Radiation pneumonitis after selective internal radiation treatment with intraarterial yttrium-90 microspheres for inoperable hepatic tumors. International Journal of Radiation Oncology, Biology and Physics 1995;33:919 - 924.